多微生物假肢关节感染:在单中心研究中揭示风险因素和结果
Álvaro Auñón1,2, Ignacio Ortiz1, Salvador Peñarrubia1
1Department of Orthopaedic Surgery, Fundación Jiménez Díaz University Hospital, 28040 Madrid, Spain.
Microorganisms
|July 30, 2025
概括
多微生物周围假肢关节感染 (PJIs) 在糖尿病和肥胖患者中更常见,导致治疗成功率明显低于单个病原体感染.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 周围假肢关节感染 (PJI) 是关节置换手术后的一种严重并发症.
- 多微生物PJIs是由多种病原体引起的,具有独特的挑战和较差的结果.
研究的目的:
- 确定多微生物PJI的风险因素,微生物特征和临床结果.
- 将多微生物PJI与单微生物PJI在三级保健环境中进行比较.
主要方法:
- 在2010年至2023年期间,对499起PJI案件进行了回顾性分析.
- 多微生物感染的定义是将≥2种病原体分离出来.
- 对人口,微生物学和临床数据的分析,包括治疗成功率.
主要成果:
- 多微生物PJI占病例的18.2%.
- 与更高的肥胖率,胰岛素依赖性糖尿病和并发症得分有关.
- 在多微生物感染 (61.5%急性,51.3%慢性) 和单微生物感染 (94.5%急性,75.3%慢性) 中观察到较低的治疗成功率.
结论:
- 多微生物PJI具有独特的微生物特征,并与患者共发病率的增加有关.
- 这些感染与显著更差的临床结果和较低的治疗成功有关.
- 优化管理需要识别多微生物PJI的特定风险因素和病原体模式.
相关概念视频
Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Endocarditis III: Medical Management
19
Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
19
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.4K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.4K
Healthcare Associated Infections II: Preventive Measures
2.8K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.8K
Acute Pyelonephritis II: Diagnostic Studies and Management
41
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
41
Endocarditis I: Introduction
26
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
26


