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Updated: Sep 13, 2025

Nanosponge Tunability in Size and Crosslinking Density
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针对药物输送的优化埃诺克索隆装载微海绵:实验设计方法

Juste Baranauskaite1, Sedef Sefer1, Augusta Zevzikoviene2

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Yeditepe University, Kayisdagi Cad., Atasehir, 34755 Istanbul, Türkiye.

Pharmaceuticals (Basel, Switzerland)
|July 30, 2025
PubMed
概括

这项研究开发了针对增强药物输送的优化素载微海绵. 这种新型配方的释放率明显更高,这表明它有可能用于治疗慢性牙周炎.

关键词:
慢性牙周炎 慢性牙周炎埃诺克索隆 (enoxolone) 是一种可靠的微型海绵是一种微型海绵.

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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