通过喷雾干燥生产的水溶性黄素和尤根醇配方
Iskra Z Koleva1, Katya Kamenova2,3, Petar D Petrov2,3
1Faculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski", 1 J. Bourchier Blvd., 1164 Sofia, Bulgaria.
Pharmaceuticals (Basel, Switzerland)
|July 30, 2025
概括
这项研究开发了一种绿色喷雾干燥方法,使用Soluplus聚合物制造水中可分散的黄素和尤根醇粉末. 该过程实现了高封装效率和快速释放,适用于营养药品和药品.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 绿色化学 绿色化学
背景情况:
- 脂性生物活性物如黄素 (Cur) 和尤根醇 (Eug) 由于水溶性差,其生物利用性有限.
- 开发有效的输送系统对于它们在营养药和药品中的应用至关重要.
- 低温喷雾干燥为封装敏感化合物提供了一种可扩展的方法.
研究的目的:
- 为了建立一个绿色和可扩展的平台,共同封装黄素和尤根醇成水溶粉.
- 为了优化配方,使用Soluplus® (SP) 和不同度的Cur和Eug.
- 评估封装生物活性物质的物理化学特性和释放特征.
主要方法:
- 使用水性或水性乙醇溶剂系统的低温喷雾干燥.
- 在单次和双重装载中,黄素 (1-10%) 和尤金醇 (5-20%) 的度各不相同.
- 加入了myo-inositol作为稳定辅助剂,以增强粉末的性能.
主要成果:
- 在使用最小的有机溶剂的情况下,实现了高负载能力 (高达10%Cur,20%Eug).
- 通过XRD和DSC确认了纳米规模的化 (53-127nm) 和生物活性物质的无形化.
- 从优化的配方中证明了高封装效率 (>95%的Cur,>93%的Eug) 和快速溶解.
结论:
- 提出了一个强大的,环保的封装策略,用于水溶性较差的植物化学品.
- 开发的粉末具有出色的物理化学性能和溶解概况.
- 该平台适用于口服营养药和制药应用,增强黄素和尤根醇的输送.
相关概念视频
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
192
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
192
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
404
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
404