对于儿科双极性障碍的卢拉西:系统性审查
Alexia Koukopoulos1, Claudia Calderoni2,3, Georgios D Kotzalidis2,3
1Department of Life Science, Health and Health Professions, Link Campus University, 00165 Rome, Italy.
Pharmaceuticals (Basel, Switzerland)
|July 30, 2025
概括
卢拉西是一种有效的治疗儿童和青少年双相情感障碍,在躁狂和抑郁症症状方面显示出积极的结果,副作用最小. 这种抗精神病药物为儿科患者提供了更安全的替代方案.
科学领域:
- 精神病学和行为科学
- 儿科心理健康 儿科心理健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 卢拉西是一种第二代抗精神病药物,已被批准用于治疗精神分裂症和情绪障碍.
- 目前治疗儿科双相情感障碍的方法存在体重增加和代谢综合征的风险.
- 卢拉西的有利副作用概况表明,它有可能成为年轻患者的替代品.
研究的目的:
- 评估卢拉西在患有双相情感障碍的儿童和青少年的疗效和安全性.
- 综合现有的关于卢拉西在患有情绪障碍的儿科患者群体中的使用证据.
主要方法:
- 使用PubMed,CINAHL,PsycINFO,Scopus和ClinicalTrials.gov.gov.的系统文献审查.
- 搜索术语包括"lurasidone"和"双极性障碍"或相关术语,过为0-18岁的人类.
- 资格标准遵循PRISMA-2020指导方针,通过德尔菲轮达成共识.
主要成果:
- 审查包括四个案例报告/系列和六个纵向研究,涉及16,735名参与者.
- 病例报告显示了混合的结果,包括一种躁狂诱导的实例.
- 纵向研究表明,对躁狂和抑郁症状的疗效通常很好.
结论:
- 卢拉西在儿科双相情感障碍方面表现出良好的结果,解决躁狂和抑郁症状.
- 药物似乎耐受良好,在这个人群中没有报告显著的不良副作用.
- 卢拉西对于患有双相情感障碍的儿童和青少年来说是一个有前途的治疗选择.
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