用于脂性药物的喷雾干燥聚合物微球:配方设计,物理化学表征和体外释放评估
Felipe Nataren-Rodríguez1, Jorge Pacheco-Molina2, Sandra Leticia Gracia-Vásquez1
1Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Av Universidad S/N, Cd. Universitaria, San Nicolas de los Garza 66455, Nuevo León, Mexico.
Pharmaceuticals (Basel, Switzerland)
|July 30, 2025
概括
优化喷雾干燥参数和聚合物选择,如胰岛素和瓜尔,显著改善脂性药物微球的生产,产量和封装效率.
科学领域:
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
- 材料科学 材料科学 材料科学
背景情况:
- 用于脂性药物微球配方的水性方法,包括喷雾干燥,存在配方挑战.
- 开发有效的微球配方需要仔细考虑工艺参数和聚合物选择.
研究的目的:
- 评估工艺参数和聚合物选择对使用水性喷雾干燥的脂性药物微球生产的影响.
- 在微球配方中优化参数以提高产量和封装效率.
主要方法:
- 使用Agave inulin, guar gum,基甲基纤维素和Eudragit® S100通过水性喷雾干燥来制备带有脂性药物载体的微球.
- 采用2^3的因数设计来分析工艺参数对产量和封装效率的影响.
- 描述了微球形态和药物释放概况.
主要成果:
- 入口温度,料流量和聚合物百分比显著影响了瓜尔微球产量和胰岛素微球封装效率.
- 胰岛素和瓜尔微球分别获得了最高的产量 (75.41%) 和封装效率 (100%).
- 瓜尔微球表现出最佳的形态,而Eudragit® S100在水性方法中失去了延迟释放的特性.
结论:
- 优化喷雾干燥参数 (入口温度,料流量) 和聚合物类型/百分比对于控制微球发展至关重要.
- 这项研究表明,特定的聚合物,如胰岛素和 guar 的潜力提高了脂性药物微球的生产.
- 可以优化水性喷雾干燥,以获得更好的产量和封装,尽管对某些聚合物控制释放仍然存在挑战.
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