抗原生菌作用的Pediococcus acidilactici-Derived 后生物对胚胎囊 ST1/ST3亚型的作用
Selahattin Aydemir1, Yunus Emre Arvas2, Mehmet Emin Aydemir3
1Department of Parasitology, Faculty of Medicine, Van Yüzüncü Yıl University, Van 65000, Türkiye.
Pathogens (Basel, Switzerland)
|July 30, 2025
概括
一种Pediococcus acidilactici后生物有效地抑制了Blastocystis,这是一种常见的肠道原生动物,与胃肠道问题有关. 这种天然剂显示出作为一种安全治疗的承诺,没有观察到对人体细胞的毒性.
科学领域:
- 微生物学 微生物学
- 寄生虫学的寄生虫学
- 胃肠病学 胃肠病学
背景情况:
- 囊胚菌是一种普遍存在的人类肠道原生动物,涉及各种胃肠道疾病.
- 胚胎囊的遗传多样性和耐治疗性需要研究新的治疗策略.
- 由于与健康问题相关,人们正在寻求天然替代品来管理胚囊菌感染.
研究的目的:
- 为了评估来自Pediococcus acidilactici的后生菌对Blastocystis的体外抗原动物活性.
- 为了描述Pediococcus acidilactici后生物的组成.
- 评估后生菌对人类肠道细胞的安全性.
主要方法:
- 培养了Pediococcus acidilactici,并收集了其后生菌并分析了其化学特性.
- 人类胚胎囊亚型ST1和ST3暴露于不同度的后生物.
- 使用显微镜评估和细胞计数套件8来确定寄生虫的生存能力和HT-29细胞的细胞毒性.
主要成果:
- 这种Pediococcus acidilactici后生物体表现出显著的抗原动物活性,在4.38 mg/ml时达到94%以上的抑制,在8.75 mg/ml时达到100%的抑制.
- 后生菌含有乳酸和化合物,具有独立于pH的抑制.
- 没有观察到HT-29细胞的细胞毒性作用,其度表明100%的胚胎囊抑制.
结论:
- 这种Pediococcus acidilactici后生物体在体外显示出强大的疗效,对抗Blastocystis亚型ST1和ST3.
- 这种后生物体代表了一个有希望的,安全的,天然的治疗候选人,用于细胞囊感染.
- 进一步的体内研究是有必要的,以验证这些发现,并探索临床应用.
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