性结肠炎中的Dientamoeba fragilis:临床发现和生物化学参数的分析
Ismail Taskiran1, Erdogan Malatyali2, Ibrahim Yildiz2
1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, Aydin Adnan Menderes University, 09010 Aydin, Turkey.
Pathogens (Basel, Switzerland)
|July 30, 2025
概括
人类常见的原生动物Dientamoeba fragilis在成人性结肠炎患者中显示出10.9%的频率. 这项研究发现D. fragilis与疾病活动或症状之间没有显著的联系,这表明其临床作用有限.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 胃肠病学 胃肠病学
- 传染性疾病 传染性疾病
背景情况:
- 丁塔梅巴 (Dientamoeba fragilis) 是一种常见的人类原生虫寄生虫.
- 它的致病性和在人类疾病中的临床意义尚未得到充分理解.
- 性结肠炎 (UC) 是一种具有复杂病因的慢性炎症性肠病.
研究的目的:
- 为了确定Dientamoeba fragilis在成人性结肠炎 (UC) 患者中的频率.
- 评估D. fragilis感染和UC的临床发现之间的关系.
- 评估与UC患者疾病特征和生化参数的关联.
主要方法:
- 未来的,单中心的,横截面的研究设计.
- 从110名成年UC患者 (2024年6月至12月) 收集的便样本.
- 聚合酶链反应 (PCR) 用于D. fragilis检测;SSUrRNA测序用于基因类型.
主要成果:
- 总的来说,D. fragilis的发病率为10.9% (12/110名患者),所有分离物都是基因型1.
- 其他已识别的原生动物包括Blastocystis sp.,大肠杆菌和Iodamoeba bütschlii.
- 在D. fragilis阳性和UC疾病阶段,症状,治疗反应或生化标志物之间没有发现显著的关联.
结论:
- 在成年性结肠炎患者中存在Dientamoeba fragilis感染,但似乎具有有限的临床作用.
- 这项研究表明,D. fragilis在这个队列中没有显著影响疾病活性或临床表现.
- 用更大的样本大小进行进一步的研究可能是有必要的,以最终确定D. fragilis在UC中的临床意义.
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