间歇性禁食作为神经保护策略:神经退行性疾病中的肠-大脑轴调节和代谢重编程
Zaw Myo Hein1, Muhammad Faqhrul Fahmy Arbain2, Suresh Kumar3
1Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
Nutrients
|July 30, 2025
概括
间歇性禁食 (IF) 通过改善肠-大脑轴功能和细胞能量来改善神经退行性疾病的前景. 这种干预可以增强大脑的弹性,并改变疾病的进展.
科学领域:
- 神经科学是一个神经科学.
- 代谢研究的研究.
- 胃肠病学 胃肠病学
背景情况:
- 神经退行性疾病 (阿尔茨海默病,帕金森病,亨廷顿病,ALS) 构成了严重的健康负担.
- 目前的治疗方法往往控制症状,而不是改变疾病的进程.
- 间歇性禁食 (IF) 是一种新兴的饮食策略,具有潜在的神经代谢益处.
研究的目的:
- 审查关于IF对神经退行性疾病影响的临床前和临床证据.
- 探索IF神经保护潜力的基础机制.
- 讨论IF的整合到神经系统疾病的精密医学.
主要方法:
- 对FI和神经退行症现有的文献进行系统审查.
- 对专注于肠-大脑轴,细胞生物能学和应激适应的研究进行分析.
- 检查分子媒介 (如SCFA,BHB,BDNF) 和生理途径 (如自,神经炎症).
主要成果:
- IF调节肠-大脑轴,重编程细胞新陈代谢,并激活压力通路.
- 有证据表明,IF支持突触可塑性,减少有毒蛋白质的积累,并恢复质/免疫均质.
- 关键介质包括短链脂肪酸 (SCFA),β-基酸 (BHB) 和来自大脑的神经营养因子 (BDNF).
结论:
- IF提供了一种灵活,可扩展的干预,有可能将神经退行从不可逆转的衰退转变为可修改的弹性.
- 与其他疗法集成的个性化IF策略具有治疗前景.
- 需要进一步的研究来解决个体变异性,优化协议,并进行伦理临床试验.
相关概念视频
01:24Metabolic States of the Body: Fasting and Starvation
1.8K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.8K
01:18Metabolic States of the Body: The Postabsorptive State
550
The postabsorptive state usually starts about four hours after a meal and lasts until the next meal is eaten. During this time, the digestive system stops absorbing nutrients, and the body uses stored energy reserves to maintain stable blood glucose levels.
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
550
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
422
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
422
00:49The Blood-brain Barrier
48.8K
Overview
48.8K
01:30Regulation of Food Intake
472
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
472
01:05Physiology of Enteric Nervous System and Gut Health
422
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
422