肥胖成年人减肥计划后肠道微生物群的变化:WLM3P研究
Vanessa Pereira1,2, Amanda Cuevas-Sierra1,3, Victor de la O3,4
1NOVA Medical School, Faculty of Medical Sciences, NMS, FCM, Nova University of Lisbon, 1169-056 Lisbon, Portugal.
Nutrients
|July 30, 2025
概括
减肥维护3阶段计划 (WLM3P) 显著改变了肠道微生物群的多样性,并增加了诸如便细菌 (Faecalibacterium) 这样的有益细菌,在六个月内增强了肥胖成年人的脂肪损失.
科学领域:
- 微生物组研究的研究.
- 肥胖管理 肥胖管理
- 营养科学 营养科学
背景情况:
- 肠道微生物群在调节肥胖和宿主能量平衡方面发挥着至关重要的作用.
- 需要有效的饮食干预措施来促进有益的微生物转移,以减肥和长期健康.
- 全球肥胖率的上升需要针对肠道微生物群的创新策略.
研究的目的:
- 调查多组分减肥维护3阶段计划 (WLM3P) 对肥胖成年人肠道微生物群组成的影响.
- 为了比较WLM3P干预措施,包括卡路里限制,高蛋白低碳水化合物饮食,时间限制饮食和补充,与标准低碳水化合物饮食 (LCD) 相比.
- 在6个月的减肥期内分析肠道微生物群的变化 (WLM3P的第一阶段和第二阶段).
主要方法:
- 一个随机对照试验 (NCT04192357) 的子分析,涉及58名肥胖成年人.
- 参与者被随机分配到WLM3P (n=29) 或LCD (n=29) 组.
- 在基线和6个月后使用16S rRNA测序分析了便样本,以评估α和β多样性,以及属级差异丰度.
主要成果:
- 与LCD组不同的是,WLM3P组在6个月后显示肠道微生物α多样性的显著增加 (p=0.03) 和β多样性的显著转变 (p<0.01),与LCD组不同.
- 差异丰度分析在WLM3P组中发现了特定的微生物特征,特别是Faecalibacterium丰度的增加.
- 与LCD组相比,在WLM3P组中,更高的便细菌丰度与脂肪质量和内脏脂肪度的更大减少显著相关 (p<0.01).
结论:
- 在WLM3P干预积极调节肠道微生物群的组成,增加多样性和特定的有益细菌.
- 在WLM3P程序中,Faecalibacterium可能在调解减肥效果,特别是减少脂肪质量方面发挥关键作用.
- 这些发现表明,一种依赖于微生物群的机制有助于WLM3P干预措施对肥胖管理的有效性.
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