高蛋白饮食干预心力衰竭:临床和功能结果的系统审查
Lorraine S Evangelista1, Rebecca Meraz2, Kelly L Wierenga2
1Sue & Bill Gross School of Nursing, University of California Irvine, Irvine, CA 92697, USA.
Nutrients
|July 30, 2025
概括
高蛋白饮食有望改善心力衰竭 (HF) 结果,增强功能能力并减少重入院. 需要进一步的研究来优化蛋白质摄入量并确认长期益处.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 心力衰竭 (HF) 与肌肉消耗,功能下降和营养不良有关.
- 高蛋白饮食是HF患者潜在的营养干预措施.
研究的目的:
- 系统地审查高蛋白饮食的随机对照试验 (RCT) 在HF人群中.
- 分析干预特征,定量效益和偏差风险.
主要方法:
- 在PubMed,MEDLINE,Embase和Cochrane CENTRAL进行了搜索,直到2025年6月.
- 包括高蛋白饮食 (≥1.1 g/kg/天) 的HF成人的RCT.
- 由于结果异质性的叙述综合;使用Cochrane RoB 2评估的偏差风险.
主要成果:
- 分析了10项试验 (1080名患者);高蛋白饮食改善了6分钟的步行距离 (+32米),瘦身量 (+1.6公斤) 和生活质量 (+9%).
- 肌肉强度的影响有所不同 (-2%至+11%);两项研究显示HF再入院率降低了18%.
- 偏差风险各不相同,包括小样本大小和短时间的随访等限制.
结论:
- 高蛋白饮食在高频功能能力和营养状况方面提供了适度,临床相关的改善.
- 观察到高频回收风险的潜在降低.
- 需要进行更大规模的试验,标准化剂量和更长的随访时间,以确认疗效和安全性.
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