美国,Ocimum americanum,在衰老过程中具有神经保护性质
Ionara Rodrigues Siqueira1, Cláudia Vanzella2, Gisele Agustini Lovatel3
1Programa de Pós-Graduação em Ciências Biológicas: Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre 90035-003, RS, Brazil.
奥西姆美洲乙醇提取物 (OAEE) 通过减少大鼠大脑组织中的氧化应激和炎症来显示神经保护作用. 这表明Ocimum americanum可能被用作衰老的功能性食物.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 老年学是一门学科.
背景情况:
- 草药药物,包括兰科的物种,正在探索老化性质.
- 关于Ocimum americanum在老鼠模型中的影响,特别是关于神经保护的研究有限.
研究的目的:
- 为了研究Ocimum americanum乙醇提取物 (OAEE) 的神经保护作用.
- 探索作用机制,重点关注氧化应激,胆酶活性和神经炎症.
- 评估OAEE对年轻成年和老龄化Wistar大鼠海马组织的影响.
主要方法:
- 用OAEE和H2O2.2对老鼠海马片进行ex vivo化.
- 在体内急性OAEE治疗评估记忆和神经化学参数.
- 在体内慢性饮食OAEE补充剂评估海马体的氧化,抗胆酶和神经炎症标志物.
主要成果:
- 在两个年龄组中,OAEE保护海马片免受H2O2诱导的损伤.
- 慢性OAEE补充剂减少了老老鼠海马中的氧化应激标志物 (反应性物种,脂质过氧化).
- 补充OAEE降低了TNF-α和IL-1β水平,表明抗神经炎症作用.
结论:
- OAEE的神经保护作用与其抗氧化和抗神经炎症作用有关.
- OAEE在预防脂氧化和减少炎症标志物方面表现出有效性.
- 这些发现支持Ocimum americanum作为一种营养或功能性食物的潜力,用于管理衰老过程.
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