针对儿科应用量身定制的口服药物治疗:可 Propranolol 凝片,由自动挤出式材料沉积方法打印
Kristiine Roostar1, Andres Meos1, Ivo Laidmäe1
1Institute of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 50411 Tartu, Estonia.
自动化半固体挤出 (SSE) 打印成功创建可 Propranolol 化凝片. 这种3D打印方法为个性化药物交付提供了一种可行的方法.
科学领域:
- 制药技术 制药技术 制药技术
- 通过3D打印,可以实现3D打印.
- 个性化医疗是个性化的医疗.
背景情况:
- 自动半固体挤出 (SSE) 是个性化药物制备的新兴技术.
- 它使用半固体聚合物印刷油墨,用于定制口服弹性凝片.
研究的目的:
- 评估自动化SSE的可行性,用于制备可凝片.
- 为了描述各种药物度的propranolol化装载凝片.
主要方法:
- 使用自动化的SSE材料沉积来制造凝片.
- 药片中含有3.0毫克,4.0毫克和5.0毫克的普拉诺洛尔化.
- 评估物理性能,机械强度和体外药物释放.
主要成果:
- 包括API降低了油墨粘度,提高了打印性能.
- 印刷的平板是弹性,可,并表现出均的机械性能.
- 在体外测试证实了即时释放的行为 (>85%的药物释放在15-20分钟内).
结论:
- 自动化SSE是一种可行的3D打印技术,用于定制的propranolol化口服凝片.
- 这种方法支持开发个性化药物配方.
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