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Updated: Sep 13, 2025

Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody Safety
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对细胞因子抗剂与药物相互作用的机械洞察:一种基于生理学的药理动力学建模方法,使用托西利祖马布作为案例研究

Xian Pan1, Cong Liu1, Felix Stader1

  • 1Certara Predictive Technologies Division, Certara UK Limited, Sheffield S1 2BJ, UK.

Pharmaceutics
|July 30, 2025
PubMed
概括

细胞因子抗剂可以通过影响肝酶来改变药物代谢. 一个新的模型准确地预测了这些相互作用,改善了对炎症性疾病的药物管理.

关键词:
在PBPK建模中使用PBPK模型.细胞因子对抗剂 细胞因子对抗剂干细胞蛋白-6 干细胞蛋白-6 干细胞蛋白治疗性蛋白质与药物相互作用这就是为什么tocilizumab.

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