水凝结合:用于药物输送的水凝的工程
Linh Dinh1, Sung-Joo Hwang2, Bingfang Yan1
1Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45229, USA.
Pharmaceutics
|July 30, 2025
概括
水凝结合精确地使水凝与治疗药物具有功能,用于先进的药物输送. 本综述详细介绍了这些创新生物材料的结合方法,治疗剂类和临床翻译潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 聚合物化学 聚合物化学
背景情况:
- 水凝是3D水友性聚合物网络,具有生物医学用途,如组织再生和药物输送.
- 水凝结合将治疗药物与水凝联系起来,使其能够控制释放,增强稳定性和创新的剂量形式.
- 这种方法支持最小入侵的管理和非病毒治疗方法.
研究的目的:
- 专注于水凝结合,用于精确的小分子和大分子的功能化.
- 审查生物结合凝系统,结合动机 (例如,点击化学) 和临床翻译潜力.
- 突出了基于核酸的水凝,用于先进生物材料的特定序列结合.
主要方法:
- 用于药物输送的水凝联合体的系统分类.
- 对基于水凝的系统的结合方法和结合动机的分析.
- 讨论各种治疗剂的设计原则,特性和药物释放概况.
主要成果:
- 根据治疗剂类别 (小分子,核酸,蛋白质) 分类水凝结合物.
- 详细介绍每个类的结合挑战,设计原则,属性和发布配置文件.
- 识别了最新的结合策略和有效的水凝药物递送的结合动机.
结论:
- 结合凝系统为先进的药物输送提供了显著的潜力.
- 需要进一步的研究来解决目前的局限性,并充分实现临床翻译.
- 基于核酸的水凝代表了一种有前途的前沿,用于特定序列的治疗交付.
更多相关视频
08:17An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components
Published on: July 18, 2018
7.3K
09:39Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
8.1K
相关概念视频
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
177
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
177
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160