吸入和注射西纳二酸盐的三部分药理动力学表明,在急性肺损伤中,长期保留和其治疗作用

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Zixin Li^1,2,3, Caifen Wang^2,4, Huipeng Xu²

¹College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.

Pharmaceutics

|July 30, 2025

概括

西纳二酸盐干粉吸入器通过减少炎症和氧化应激,有效治疗急性肺损伤 (ALI). 这种新型配方提供了改善的药理动力学和向的肺输送,以获得更好的治疗结果.

科学领域:

药理学药理学是指药理学的学科.
药物运输药物运输药物运输
毒理学毒理学毒理学

背景情况:

急性肺损伤 (ALI) 涉及炎症和氧化应激,导致高死亡率.
来自Sinapis Semen Albae的西纳二酸盐 (ST) 具有抗炎和抗氧化特性.
没有单一的ST药物配方;干粉吸入器 (DPI) 提供向的肺部输送.

研究的目的:

开发和评估用于ALI治疗的ST的可吸入干粉配方.
阐明ST DPI的治疗机制和药物动力学特征.
为了验证ST DPI在LPS诱导的ALI大鼠模型中的疗效.

主要方法:

使用抗溶剂结晶,ST被净化并制成可吸入的颗粒.
使用网络药理学和药理动力学分析来了解ST的机制.
在LPS诱导的老鼠ALI模型中评估了治疗疗效.

主要成果:

该ST DPI表现出有利的空气动力学特性和三指数的药理动力学特征.
与口服 gavage 相比,通过吸入施用ST导致延长全身停留时间和增加AUC (2.7倍).
通过降低炎症性细胞因子的调节,减少氧化应激,并调节MAPK介导的亡,ST DPI显著减轻了ALI.

结论:

该ST DPI为ALI提供了一个有前途的,药理动力学驱动的治疗策略.
该配方有效地减轻了炎症,氧化应激和肺损伤.
独特的药理动力学特征支持其用于治疗肺部疾病.

关键词:

在 MAPK 信号通道中.肺部急性肺损伤是什么干粉吸入器的使用方法药物动力学药物动力学西纳二氧化酸酸.

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