基于电纳米纤维的多层透皮贴片平台的开发,用于输送咖啡因
Jorge Teno1, Zoran Evtoski2, Cristina Prieto2
1R&D Department, Bionanopharma S.L., Calle Algepser 65 nave 3, 46980 Paterna, Valencia, Spain.
Pharmaceutics
|July 30, 2025
概括
这项研究开发了一种新的通过皮肤注射咖啡因补丁,使用电纤维. 该贴片有效地通过皮肤输送咖啡因,证明了增强药物输送系统的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物医学工程 生物医学工程
背景情况:
- 通过皮肤递送药物系统的开发对于有效和可控的治疗管理至关重要.
- 电是一种多功能技术,用于制造用于药物封装的超薄纤维.
研究的目的:
- 创建和表征一个通过皮肤的咖啡因平台使用电微和亚微纤维.
- 评估透增强剂对咖啡因通过皮肤传递的影响.
主要方法:
- 用含咖啡因的聚乙烯氧化物 (PEO) 纤维和聚烯酸 (PCL) 支持制造多层补丁.
- 使用SEM,ATR-FTIR,DSC和WAXS进行表征.
- 在体外透研究中,使用具有合成膜和人类角层的弗朗茨细胞进行了透研究.
主要成果:
- 成功制造了一种多层透皮贴片.
- 透增强剂显著调节咖啡因释放率.
- 在24小时内达到高达0.73mg/cm2的咖啡因透率.
结论:
- 电液动力处理是开发先进的透皮输送系统的一个有前途的技术.
- 开发的贴片显示了提高药物疗效和创新的治疗管理的潜力.
相关概念视频
Drug Delivery: Miscellaneous Routes
468
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
468
Drug Delivery: Overview
426
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
426


