癌症干细胞的临床前试验以金属为基础的协调复合体为目标:系统性审查
Ana Caroline Mafra Bezerra1, Lucas Elohim Cardoso Viana Baptista1, Maria Núbia Alencar Couto1
1Center for Biosciences and Biotechnology, Darcy Ribeiro State University of Northern Fluminense, Campos dos Goytacazes 28013-602, Brazil.
Pharmaceutics
|July 30, 2025
概括
金属协调复合物,特别是基于铜的化合物,在向癌症干细胞 (CSCs) 中表现有前途. 这些药物诱导亡并调节CSC标记物,为新的癌症疗法提供了潜力.
科学领域:
- 药用化学 医学化学
- 在瘤学瘤学.
- 纳米技术 纳米技术
背景情况:
- 癌症干细胞 (CSCs) 驱动瘤异质性和治疗耐药性.
- 有限有效的治疗剂针对CSC.
- 基于金属的协调复合物正在被探索为新型抗CSC剂.
研究的目的:
- 系统地审查金属基协调复合物的临床前证据作为抗CSC剂.
- 在CSC模型中评估这些化合物的疗效和机制.
主要方法:
- 按照PRISMA指南进行系统的文献搜索.
- 包括27项实验室研究,评估CSC丰富的癌症细胞系上的金属化合物.
- 对研究的方法质量进行批判性评估.
主要成果:
- 基于铜的金属复合物对CSCs表现出显著的细胞毒性,主要是通过诱导亡.
- 经常报告关键的CSC标志物 (例如CD44,CD133,SOX2) 的调节.
- 乳腺癌是研究最多的瘤类型;大多数研究都是体外和来自英国的.
结论:
- 金属协调复合物,特别是基于铜的复合物,对CSCs具有治疗潜力.
- 进一步的体内研究和机制研究对于临床转化至关重要.
- 这些化合物可能提供一种新的策略,以克服CSC介导的治疗耐药性.
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