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Updated: Sep 13, 2025

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在COVID-19的糖尿病患者中血清sICAM-1和galactin-3水平

Busra Karahan¹, Dogan Nasir Binici¹, Omer Karasahin²

¹Department of Internal Medicine, Erzurum Regional Training and Research Hospital, Erzurum 25240, Türkiye.

|July 30, 2025

概括

可溶性细胞间粘附分子-1 (sICAM-1) 和加勒-3显示为COVID-19患者2型糖尿病 (T2D) 的诊断标记物具有前途. 然而,这些标志物并不能预测研究中的队列中的生存结果.

科学领域:

内分泌学在内分泌学.
免疫学免疫学免疫学
传染性疾病传染性疾病

背景情况:

2型糖尿病 (T2D) 是严重的COVID-19结局的重要危险因素.
需要生物标志物来评估COVID-19的T2D患者的疾病严重程度和预后.

研究的目的:

为了评估可溶性细胞间粘附分子-1 (sICAM-1) 和加勒-3的诊断和预后价值.
在T2D和COVID-19患者中评估这些标记物.

主要方法:

45名COVID-19的T2D患者和45名健康对照者的前性观察研究.
使用ELISA测量了sICAM-1和galectin-3的血清水平.
患者与对照者之间,以及幸存者与非幸存者之间生物标志物水平的比较.

主要成果:

与对照人群相比,COVID-19的T2D患者的 galectin-3 和 sICAM-1 血清水平显著升高 (p < 0.001).
在幸存者和不幸存者之间,加勒-3或sICAM-1水平没有显著差异 (p = 0.240和p = 0.266).

结论:

在COVID-19的T2D患者中,加勒-3和sICAM-1表现出比传统生物标志物更好的诊断效用.
高水平表明糖尿病COVID-19患者的系统性炎症.
加勒-3和sICAM-1之间的强烈相关性表明潜在的共享炎症途径.

关键词:

冠状病毒疾病是新冠肺炎的疾病.在糖尿病中,糖尿病是血糖性糖尿病.盖莱克-3的使用方法在SICAM-1中使用.

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