孕产妇肥胖改变了活跃SARS-CoV-2感染对胎盘病理的影响
Francisca Carmo1,2, Carla Ramalho3,4, Susana Guimarães5,6
1Unit of Biochemistry, Department of Biomedicine, Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal.
Viruses
|July 30, 2025
概括
孕产妇肥胖与SARS-CoV-2感染相结合,增加了胎盘缺血损伤的风险. 这些胎盘变化特定于肥胖的母亲,突出显示了COVID-19大流行期间肥胖对怀孕结果的影响.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 孕期肥胖增加了严重的COVID-19风险,导致孕产妇和新生儿并发症.
- SARS-CoV-2 感染和孕产妇肥胖对胎盘病理的综合影响仍未得到充分研究.
研究的目的:
- 为了比较肥胖与非肥胖的怀孕个体与活跃的SARS-CoV-2感染的胎盘组织病理变化.
主要方法:
- 回顾性队列研究分析人类胎盘.
- 组包括:感染SARS-CoV-2的肥胖 (OB+SARS) 和非肥胖 (SARS) 妇女,以及对照组 (肥胖的OB和非肥胖的控制组).
- 从大流行和大流行前的时期收集了胎盘.
主要成果:
- 与对照组相比,OB+SARS组的缺血损伤和底纤维素沉积率高出50% (风险增加15倍).
- 在OB+SARS组中,胆病风险比肥胖对照组 (OB) 低10%.
结论:
- 感染SARS-CoV-2的孕妇的肥胖与胎盘病变的增加有关,包括缺血性损伤和 malperfusion.
- 这些胎盘变化是肥胖母亲特有的,而不是在非肥胖女性中观察到的.
- 这些发现强调了孕产妇肥胖在COVID-19期间怀孕并发症中的关键作用.
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