Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cancer Vaccines01:30

Cancer Vaccines

514
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
514
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

345
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
345
Vaccinations01:51

Vaccinations

45.3K
Overview
45.3K
Development of Immunocompetence01:22

Development of Immunocompetence

449
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
449

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Efficacy and Safety of Glutathione Supplementation in Type 2 Diabetes & Diabetes Complications.

Nutrients·2026
Same author

Systematic Review: The Impact of COVID-19 Vaccination on Myocarditis Risk and Recovery.

Clinics and practice·2026
Same author

Autoimmune Diseases and Mycobacterial Infection.

Diseases (Basel, Switzerland)·2026
Same author

The Evolution of Symbiosis in <i>Staphylococcus epidermidis</i>: From a Protective Mutualist to a Parasitic Pathogen.

Biomolecules·2026
Same author

Glutathione-Mediated Redox Regulation of Immune Dysfunction in COVID-19 and Tuberculosis.

Antioxidants (Basel, Switzerland)·2026
Same author

Diagnostic Imaging of Extrapulmonary Tuberculosis Across Organ Systems.

Diagnostics (Basel, Switzerland)·2026

相关实验视频

Updated: Sep 13, 2025

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

11.3K

艾滋病毒疫苗研究的进展和最近的发展

Iris Shim1, Lily Rogowski1, Vishwanath Venketaraman1

  • 1College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.

Vaccines
|July 30, 2025
PubMed
概括

几十年来,人类免疫缺陷病毒 (HIV) 疫苗研究表明,尽管面临挑战,仍有进展. 早期的试验失败了,但RV144试验提供了部分保护,指导了未来有效艾滋病毒疫苗的策略.

科学领域:

  • 免疫学 免疫学 免疫学
  • 疫苗学 疫苗学 疫苗学
  • 传染性疾病 传染性疾病

背景情况:

  • 人类免疫缺陷病毒 (HIV) 仍然是一个全球性的健康问题.
  • 开发一种有效的艾滋病毒疫苗是具有挑战性的,因为病毒的遗传变异性和突变率.
  • 抗逆转录病毒疗法和预防策略已经进步,但疫苗至关重要.

研究的目的:

  • 从20世纪90年代末到2025年全面审查艾滋病毒疫苗候选人和临床试验进展.
  • 追踪艾滋病毒疫苗策略的演变.
  • 综合 1-3 期试验的研究结果.

主要方法:

  • 在PubMed和ClinicalTrials.gov搜索了英语HIV疫苗试验 (1-3期).
  • 从1990年到2025年3月发表的相关试验的选标题,摘要和全文.
  • 提取了关于试验阶段,治疗方案,免疫性,疗效和相关的数据;以叙事方式综合了发现.

主要成果:

  • 早期的蛋白质亚单元疫苗是无效的,强调了需要全面的免疫反应 (抗体和T细胞).
  • 针对单独针对T细胞反应的病毒载体试验不足.
  • 2009年RV144试验证明了部分保护,影响了随后的研究,以探索复杂的免疫反应和组合技术.
关键词:
艾滋病病毒 艾滋病病毒 艾滋病病毒疫苗的有效性 疫苗的有效性疫苗,疫苗的使用情况.

更多相关视频

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

7.7K
Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
13:58

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

31.7K

相关实验视频

Last Updated: Sep 13, 2025

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals
09:27

New Tools to Expand Regulatory T Cells from HIV-1-infected Individuals

Published on: May 30, 2013

11.3K
Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

7.7K
Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
13:58

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays

Published on: September 26, 2011

31.7K

结论:

  • 尽管有挫折,但广泛的研究已经为艾滋病毒疫苗开发做出了重大贡献.
  • 目前正在进行的努力继续推进对艾滋病毒的理解,并完善疫苗策略.
  • 新技术正在被采用,以实现对艾滋病毒感染的强大,持久的免疫力.