在接种COVID-19疫苗的医院护士中,核因子红色素2-相关因子2和SARS-CoV-2感染风险
Stefano Rizza1, Luca Coppeta2, Gianluigi Ferrazza1
1Department of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Vaccines
|July 30, 2025
概括
在医疗保健工作者中,核因子红色素衍生的2样2 (NRF2) 基因表达的更高水平与SARS-CoV-2感染的减少和更好的睡眠质量相关. 这表明NRF2可能在COVID-19耐药性和疫苗疗效方面发挥作用.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 职业健康 职业健康 职业健康
背景情况:
- 医疗保健工作者 (HCW) 面临高SARS-CoV-2暴露风险.
- 背后的机制HCW的明显抗感染的机制还没有完全理解.
- 研究炎症和昼夜节律在SARS-CoV-2易感性中的作用.
研究的目的:
- 探索志愿医院护士 (VHNs) 炎症,昼夜干扰和SARS-CoV-2耐药性之间的关系.
- 评估核因子红色素衍生的2样2 (NRF2) 基因表达在SARS-CoV-2感染率中的作用.
- 检查NRF2表达,睡眠质量和COVID-19疫苗接种之间的关联.
主要方法:
- 对246名接种疫苗的VHNs进行了回顾性队列研究.
- 使用匹兹堡睡眠质量指数评估睡眠质量.
- 测量炎症介质和昼夜转录因子,包括外围血液单核细胞中的NRF2基因表达.
主要成果:
- 在从未感染过SARS-CoV-2的VHNs中观察到显著更高的NRF2基因表达,与之前感染的人相比 (p < 0.01).
- NRF2表达水平与接收的COVID-19疫苗数量没有关联 (p = 0.598).
- 较高的NRF2基因表达与自我报告的更好的睡眠质量相关 (p < 0.01).
结论:
- 这些发现表明NRF2基因表达对抗SARS-CoV-2感染的潜在保护作用.
- NRF2可能会影响COVID-19疫苗接种的有效性.
- 睡眠质量似乎与NRF2表达和潜在的SARS-CoV-2耐药性有关.
更多相关视频
08:41Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
2.9K
10:25Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
Published on: June 5, 2021
4.8K
相关概念视频
Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Nurses' Legal Responsibilities II
816
Establishing a secure, collaborative nurse-patient relationship is crucial for delivering high-quality care. This relationship, founded on trust, respect, and honesty, enhances the patient's comfort and willingness to share vital health information. For example, a nurse who listens actively and without judgment provides clear information about health conditions and treatment options and respects patient decisions, which builds a trusting relationship.
Communication between nurses and...
Communication between nurses and...
816
Nurses' Legal Responsibilities I
863
In healthcare, informed consent is a crucial process that involves thoroughly communicating medical treatment options to patients, including benefits, risks, potential side effects, and alternatives. This process enables patients to make well-informed decisions about their care, ensuring they understand the implications of their choices before consenting to or refusing treatment.
The legal responsibilities of a nurse regarding informed consent include the following:
The legal responsibilities of a nurse regarding informed consent include the following:
863
Nurses' Legal Responsibilities III
756
Nurse-to-nurse relationships are legally required to adhere to professional standards, ensuring a respectful and positive working environment. Professional conduct demands that nurses treat all colleagues respectfully and courteously, fostering a productive, supportive workplace. Nurses must actively eliminate bullying, discrimination, and harassment to maintain a safe and inclusive environment.
Cultivating a culture of collaboration and mutual respect among nurses transcends mere enhancement...
Cultivating a culture of collaboration and mutual respect among nurses transcends mere enhancement...
756
Relative Risk
348
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
348
Rous Sarcoma Virus (RSV) and Cancer
5.4K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.4K
