XBB.1.5 COVID-19 mRNA 疫苗在患有炎症性肠病的患者中诱导了不足的粘膜免疫力
Simon Woelfel1,2,3, Joel Dütschler1,4, Daniel Junker5
1Department of Gastroenterology and Hepatology, HOCH, Cantonal Hospital St. Gallen, 9007 St. Gallen, Switzerland.
在炎症性肠病 (IBD) 患者中,COVID-19 mRNA 疫苗有效地促进粘膜IgG,但未能诱导保护性粘膜IgA. 这表明需要新的粘膜疫苗来增强IBD人群中SARS-CoV-2的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 胃肠病学 胃肠病学
背景情况:
- 粘膜免疫对于预防SARS-CoV-2感染至关重要.
- COVID-19 mRNA疫苗在炎症性肠病 (IBD) 患者中诱导全身免疫力,但粘膜反应仍然不清楚.
- 这项研究调查了在免疫功能低下的IBD患者接种XBB.1.5mRNA疫苗后的粘膜免疫力.
研究的目的:
- 评估XBB.1.5mRNA疫苗在IBD患者的粘膜免疫反应中产生的疗效.
- 在接种疫苗之前和之后,量化唾液中的IgG和IgA抗体水平.
- 为了比较粘膜反应与系统反应以及健康个体的先前发现.
主要方法:
- 在IBD患者的唾液IgG和IgA向SARS-CoV-2 JN.1受体结合域的纵向分析.
- 使用MultiCoV-Ab多重复合免疫试验进行抗体量化.
- 在接受了前三剂COVID-19疫苗的患者中,比较了疫苗接种前和后的抗体水平.
主要成果:
- XBB.1.5 mRNA疫苗显著增加了粘膜IgG水平 (p = 0.0013).
- 粘膜IgA水平在接种疫苗后没有显著变化 (p = 0.8233).
- 疫苗接种并没有诱导IBD患者的血清IgA,与健康个体不同.
结论:
- 在IBD患者中,COVID-19 mRNA疫苗未能引起显著的粘膜IgA反应.
- 缺少粘膜IgA表明对SARS-CoV-2感染的保护不足.
- 开发特定的粘膜COVID-19疫苗是有必要的,以加强IBD人群的保护.
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