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与癌症相关的突变和多重血清酸化对多 (ADP-ribose) 聚合酶2的影响

Bridget Hughes1, Shubham Chatterjee2, Mozhdeh Ghafari2

  • 1Department of Physics, University of Dallas, Irving, Texas.

Biophysical journal
|July 30, 2025
PubMed
概括

在Poly (ADP-ribose) 聚合酶2 (PARP2) 上的翻译后修改 (PTM) 有助于保存其野生型 (WT) 结构和功能,即使存在癌症相关突变. 这些PTM减轻了PARP2.2中D235G突变引起的结构和动态变化.

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