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Updated: Sep 13, 2025

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IDH突变对连接体解结的影响:从定向分子动力学的见解

Alka Singh1, Sonia Kumari1, M Elizabeth Sobhia1

  • 1Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar (Mohali), 166062, Punjab, India.

Current topics in medicinal chemistry
|July 30, 2025
PubMed
概括

异酸脱酶 (IDH) 酶的突变破坏了α-谷氨酸 (AKG) 的结合,改变了酶的稳定性. 这可能解释了2-基酸盐 (2-HG) 的积累,并导致癌症的发展.

关键词:
异酸脱基酶的异酸.在MM/GBSA.结合性亲和力是一种结合性亲和力.突变是发生在突变中的突变.引导了分子动力学.

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