癌化学放射治疗后患者报告的结果
Kathinka Schmidt Slørdahl1, Eva Skovlund2, Jan-Åge Olsen3
1Department of Oncology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. katslo@ous-hf.no.
门癌的化学放射治疗可以改善生存率,但会导致长期问题. 患者经历了治疗后5年的持续性阳和性功能障碍以及慢性疲劳.
科学领域:
- 在瘤学瘤学.
- 患者报告的结果
- 临床研究 临床研究
背景情况:
- 化疗放射治疗 (CRT) 是对门状细胞癌 (SCCA) 的标准治疗方法.
- 为了患者的福祉,平衡治疗效果与长期副作用至关重要.
- 了解患者报告的结果 (PRO) 对于优化SCCA管理至关重要.
研究的目的:
- 在接受CRT的SCCA患者中前性评估患者报告的结果 (PRO).
- 评估症状的发展轨迹和功能状态,从治疗前到CRT后5年.
- 确定与治疗相关的持续性毒性及其对生活质量的影响.
主要方法:
- 一项前性研究涉及120名接受CRT的SCCA患者 (54-58 Gy与线粒素和5-甲).
- PRO问卷 (EORTC QLQ-C30,QLQ-CR29,圣马克斯失禁得分,疲劳问卷,HADS,神经性得分) 在CRT前和CRT后3个月,1,3个月和5年进行.
- 分析的重点是随着时间的推移,症状和功能结果的变化.
主要成果:
- 在治疗前,患者报告了显著的症状负担和功能障碍.
- 与瘤相关的症状,如部疼痛,在CRT后得到改善,与瘤反应保持一致.
- 然而,身体形象恶化,阳和性功能在CRT治疗5年后仍然持续受损.
- 焦虑随着时间的推移而改善,但慢性疲劳 (CF) 影响了28%的患者在5年的随访.
结论:
- 对SCCA的CRT导致长期的后果,特别是在直肠和性功能方面.
- 治疗后5年,很大一部分患者经历了慢性疲劳.
- 这些发现凸显了对SCCA幸存者的持续支持性护理和晚期副作用管理的需要.
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