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最近分子光声断层扫描技术的进展

Eric Hall^1,2, Chengyun Tang¹, Lei Li^1,3

¹Department of Electrical and Computer Engineering, Rice University, Houston, TX, United States of America.

JPhys photonics

|July 30, 2025

概括

光声断层扫描 (PAT) 通过结合光学和超声波特性提供深层组织成像. 分子PAT使用特定的光吸收在体内针对性分子成像.

科学领域:

生物医学成像学生物医学成像学
光学成像技术的使用.
超声波成像超声波成像

背景情况:

光声断层扫描 (PAT) 将光学灵敏度与超声波分辨率相结合,用于深层组织成像.
分子PAT利用特定的分子光吸收进行有针对性的可视化.
PAT使内源和外源对比剂的体内成像成为可能.

研究的目的:

突出分子光声学断层扫描在生物医学成像中的功能.
讨论 PAT 中各种分子对比剂的优点.
展示PAT在医学诊断和研究中的潜力.

主要方法:

利用分子的特定光学吸收特征.
调整激发波长以针对特定的分子对比度.
一系列内源性 (血红蛋白,黑色素,脂质) 和外源性 (染料,蛋白质,纳米颗粒) 剂的成像.

主要成果:

在体内,PAT可以选择性地绘制各种分子点的图像.
内生对比提供非侵入性成像,但特异性有限.
外源对比度为分子成像提供了增强的特异性和灵敏性.

结论:

分子PAT显示出诊断,监测和治疗疾病的巨大潜力.
对比剂的进步提高了光声成像在生物研究中的实用性.
PAT是一种强大的工具,用于研究基本的生物过程 in vivo.

关键词:

内源的对比度是内源的.外源的对比度是外源的对比度分子成像分子成像技术分子光声断层扫描 (MOCT) 是一种分子光声断层扫描.光声显微镜 (PAM) 的使用光声断层扫描 (PAT) 是一种光声断层扫描.

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