肠球菌性细菌病的概述与潜在的治疗选择
Ekadashi Rajni1, Ayushi Jorwal1, Kriti Goyal2
1Department of Microbiology, Mahatma Gandhi University of Medical Sciences and Technology, Jaipur, Rajasthan, India.
概括
越来越令人担忧的是,抗万科米辛的肠杆菌 (VRE) 细菌病. 这项研究发现VRE患病率为8.73%,治疗选择有限,强调需要更好的感染控制和抗生素管理.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 临床药房 临床药房
背景情况:
- 肠球菌,特别是抗万科胺素抗性肠球菌 (VRE),由于病原性和抗菌素耐药性增加,存在重大临床挑战.
- 了解菌细菌病的当地流行病学和抗菌素敏感性对于有效的患者管理至关重要.
研究的目的:
- 为了确定肠球菌细菌病的患病率.
- 为了分析Enterococcal分离物的抗生素敏感性模式.
- 突出抗药性模式的临床影响,并为抗微生物药物管理提供信息.
主要方法:
- 在第三级护理教学大学医院进行了一项回顾性观察性研究.
- 分析了从2022年10月到2023年9月的血液培养.
- 使用自动化系统 (BD BACTEC,VITEK 2 Compact) 按照CLSI指南进行了物种识别和抗生素敏感性测试.
主要成果:
- 肠球菌 (Enterococcus spp.) 是一种细菌. 占阳性血液培养的30.14%,其中Enterococcus faecium是最常见的物种 (85.71%).
- 在VRE的患病率为8.73%. 所有VRE分离物都对zylpenicillin和诺基诺产生了耐药性,80%对linezolid产生了耐药性.
- 观察到百分之百的敏感性达普托米辛和tigecycline对VRE分离物.
结论:
- 该研究强调了VRE的严重流行,强调需要采取严格的感染控制措施.
- 谨慎的抗生素管理对于有效管理和预防VRE感染至关重要.
- 达普托米辛和tigecycline代表了对VRE感染的潜在治疗选择.
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