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耐火性突发感神经听力损失的救援治疗策略 - 一个全面的综述和元分析,附有实际建议的元分析

Piero Giuseppe Meliante^1,2, Luigi D'Avino², Giuseppe Barba²

¹Department of Neuroscience, Mental Health and Sensory Organs (N.E.S.M.O.S.), Faculty of Medicine and Psychology, "Sapienza" University, Rome, Italy.

Frontiers in neurology

|July 30, 2025

概括

拯救性治疗,如入耳性类固醇和高压氧气疗法,可以改善对初始治疗无反应的突然感觉神经听力损失 (SSNHL) 的听力. 早期干预和特定类型的类固醇可以改善SSNHL患者的治疗结果.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
神经学神经学
再生医学是一种再生医学.

背景情况:

突发感应神经听力损失 (SSNHL) 每年影响许多人,超过一半的人在标准治疗后经历了持续的听力损失.
确定有效的救援治疗对于耐火性SSNHL病例至关重要,以尽量减少长期的听力障碍.

研究的目的:

系统地审查对初始系统性皮质类固醇治疗没有反应的SSNHL的救援治疗方法.
开发一种基于证据的治疗算法,用于耐火性SSNHL.

主要方法:

在PubMed,Embase和Cochrane图书馆 (2010-2025) 进行了全面的文献搜索.
包括的研究包括临床试验和大型病例系列,评估SSNHL的救援干预措施.
使用ROBINS-I工具评估了偏差风险.

主要成果:

内类固醇 (ITS),特别是甲基prednisolone,以及高压氧气疗法 (HY) 显示出一致的有效性.
结合ITS和HY在文字识别和纯色调平均 (PTA) 改进方面取得了最好的结果.
早期ITS启动改善了结果,特别是高频SSNHL和耳;约束诱导声疗法 (CIST) 显示出有前途.

结论:

内类固醇 (ITS) 和高压氧疗法 (HY),特别是组合使用,是耐火性SSNHL的有效救援疗法.
甲基普雷迪尼索隆可能优于德克萨米他;早期干预仍然至关重要.
约束诱导的声音疗法 (CIST) 通过解决皮质适应不良的情况,显示出改善结果的潜力.

关键词:

葡萄糖皮质类药物/治疗用途听力损失听力损失是什么高压氧化 (HBO) 是指高压氧化.内膜内注射内膜内注射这是一个突然的突然,突然的突然.治疗结果治疗结果

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