翻译后的修改在心血管疾病中协调mTOR驱动的细胞死亡
Jiawei Guo1,2, Yiting Wu3, Zhengdong Wan1
1Department of Vascular and Endovascular Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, China.
Frontiers in cardiovascular medicine
|July 30, 2025
概括
翻译后修改 (PTMs) 关键调节了拉巴胺素 (mTOR) 途径的机械性标,影响了心血管疾病. 针对这些PTM和mTOR轴为心血管医学提供了有前途的治疗策略.
科学领域:
- 生物化学和分子生物学
- 心血管生物学 心血管生物学
- 细胞生理学 细胞生理学
背景情况:
- 拉巴胺素 (mTOR) 途径的机械性标控制了基本的细胞过程,如新陈代谢,生长和细胞死亡.
- mTOR信号的调节失调,经常受到后翻译性修改 (PTM) 的影响,与心血管疾病 (CVD) 有关.
研究的目的:
- 审查了解心血管病理生理学中mTOR信号的PTM介导控制的最新进展.
- 突出针对PTM或心血管疾病的mTOR轴的新兴治疗策略.
主要方法:
- 对心血管环境中的mTOR信号和PTMs当前文献的系统综述.
- 对PTM的分析 (酸化,无化,SUMOylation等) 影响到mTOR调节器和效应器.
- 检查针对PTM和mTOR途径的治疗干预措施.
主要成果:
- 在心血管应激期间,PTM 微调 mTOR 活动,影响细胞命运决定 (细胞亡,自亡,热亡,铁亡).
- 异常PTM有助于动脉样硬化,心肌梗塞,心力衰竭和缺血-再输血损伤的发病.
- 各种治疗药物,包括mTOR抑制剂和SUMOylation调节剂,在临床前或临床上显示出前景.
结论:
- 了解PTM-mTOR相互作用对于阐明心血管病理生理学至关重要.
- 准PTM和mTOR轴为心血管医学和精密疗法提供了新的治疗途径.
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