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易挥发性有机化合物暴露与美国成年人肉症相关,来自NHANES 2011-2018年
Pangbo Wang1,2,3, Wei Chen4, Hongwei Fang5
1Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Chongqing, China.
Frontiers in public health
|July 30, 2025
概括
暴露于多种挥发性有机化合物 (VOCs) 与肉症风险有关. 这种关联可能涉及内分泌和炎症途径,潜在的调解者包括性酸酶和维生素D水平.
科学领域:
- 环境健康 环境健康
- 老年学是一门学科.
- 毒理学 毒理学 毒理学
背景情况:
- 挥发性有机化合物 (VOC) 是公认的环境污染物,具有潜在的健康影响.
- 尿液中的VOC代谢物 (mVOCs) 与肌肉损失特征的一种疾病 - - 肉症之间的特定关系尚不清楚.
研究的目的:
- 为了调查尿路mVOC暴露与肉类的患病率之间的关联.
- 探索mVOC暴露对肉症风险的联合影响和潜在的介导途径.
主要方法:
- 利用了来自全国健康和营养检查调查 (NHANES 2011-2018) 的数据,其中有2,898名参与者.
- 采用多变量逻辑回归,受限立方线 (RCS),加权量子总和 (WQS) 回归和贝叶斯核心机器回归 (BKMR) 模型.
- 进行调解和网络药理学分析,以确定潜在的生物机制和途径.
主要成果:
- 在几种mVOC和肉症之间观察到正相关性.
- 剂量反应相关性得到证实,在老年人中更强烈的联系.
- WQS和BKMR模型表明,总体VOC暴露与肉症风险之间存在一致的正相关性.
- 确定的调解剂包括性酸酶 (ALP),白细胞计数 (WBC),全身免疫炎症指数 (SII) 和维生素D.
结论:
- 同时暴露于挥发性有机化合物与增加的萨尔科佩尼亚风险有关.
- 这些发现表明,内分泌和炎症通路的破坏是潜在的机制.
- 升高的ALP,WBC,SII和降低的维生素D水平,以及内分泌抵抗途径的丰富,突出显示了关键的生物学变化.
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