抗原动物治疗与减少人口死亡率之间的关联表明,原生动物殖民可能对人类死亡率和与年龄相关的发病率有重大贡献
medRxiv : the preprint server for health sciences
|July 30, 2025
概括
某些抗原动物药物,如阿托瓦昆-普罗瓜尼尔和美弗洛,显示出增加人类寿命的潜力. 这些药物可能会降低死亡率和与年龄相关的疾病,但会带来特定副作用的风险.
科学领域:
- 老年学和长寿研究研究.
- 药理学和药物发现
- 传染病和寄生虫学 传染病和寄生虫学
背景情况:
- 确定延长人类寿命和促进健康衰老的干预措施是研究的一个关键领域.
- 慢性感染,如原生动物寄生虫感染,在与年龄相关的发病率和死亡率中的作用越来越被认可.
研究的目的:
- 系统地查药物是否有可能延长人类寿命.
- 调查特定抗原动物剂与寿命之间的关联.
- 在独立人群中验证发现,并评估相关风险和益处.
主要方法:
- 来自国家卫生组织的电子健康记录的系统选,比较长寿个体的药物使用与匹配的对照.
- 使用美国的TrinetX联合网络验证已识别的协会.
- 统计分析包括赔率比率和错误发现率 (FDR) 以评估显著性.
主要成果:
- 两种抗原虫药物,阿托瓦昆-普罗古尼尔和美弗洛昆,与延长寿命有很强的关联.
- 另一种抗原动物药物尼尔马特里尔维尔-里托纳维尔也与降低死亡率和较低的与年龄相关的主要疾病 (糖尿病,心血管,脑血管,脏,痴呆症,肺,肝脏,恶性病) 发病率有关.
- 抗生素暴露与听力损失,Sjögren综合征和平的风险增加有关.
结论:
- 消除原生虫寄生虫,如Toxoplasma gondii,可以显著降低与年龄相关的发病率和死亡率.
- 有针对性的抗微生物干预措施显示出延长人类寿命和促进健康衰老的前景.
- 必须权衡潜在的益处与特定不良结果的风险,包括听觉,眼科和皮肤学并发症.
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