全脑功能连接性预测了临床前阿尔茨海默病中区域性tau PET
Hamid Abuwarda1,2, Anne Trainer1, Corey Horien2
1Department of Neurology, Yale School of Medicine, New Haven, CT 06519, USA.
Brain communications
|July 30, 2025
概括
功能连接性预测在临床前阿尔茨海默病中tau PET,优于粉样蛋白PET预测. 这些发现表明,功能连接组有助于早期检测阿尔茨海默氏症的病理,特别是在后期的区域.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 计算生物学 计算生物学
背景情况:
- 临床前阿尔茨海默氏症 (AD) 涉及在认知衰退之前粉样β的积累,提供了一个干预窗口.
- 之前的研究指出,在临床前阿尔茨海默病的功能连接性 (FC) 变化,但它对阿尔茨海默病理学的预测作用未被探索.
- 早期发现AD病理对于及时干预和管理至关重要.
研究的目的:
- 在临床前阿尔茨海默病中研究休息状态全脑功能连接 (FC) 对和粉样蛋白-β PET 结合的预测能力.
- 为了确定FC是否可以预测区域TAU PET信号,优于粉样PET的预测.
- 在独立的数据集中验证基于FC的预测模型,并确定与病理相关的关键连接模式.
主要方法:
- 基于Connectome的预测建模应用于静止状态的功能连接数据.
- 模型预测了TAU (18F-flortaucipir) 和粉样蛋白-β (18F-florbetapir) 在临床前阿尔茨海默症参与者的PET结合 (A4研究).
- 模型性能使用斯皮尔曼相关性进行评估,并在外部数据集 (ADNI-3) 上进行验证.
主要成果:
- 全脑FC显著预测了区域TAU-PET结合,超过了粉样PET的预测.
- 最好的tau预测模型是影响后期布拉克阶段 (IV-V) 的地区,而早期阶段的地区显示出较差的预测.
- 基于FC的模型成功地从外部数据集中预测了tau-elevated个体中的tau PET,证明了可概括性.
结论:
- 功能连接在临床前阿尔茨海默病中有意义地预测了tau PET,特别是在与高级病理学相关的区域.
- 这些预测模型显示了早期发现和监测阿尔茨海默病的潜力,特别是在后期目标地区.
- 这些发现表明,功能连接在早期的AD过程中起着关键作用,这可能会促进后来的tau传播.
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