一个基于免疫炎症指标的诺莫图,用于5岁以下儿童的罗塔病毒性腹:单中心回顾性队列研究
Jing Chen1, Xiao Chen2, Xiaoling Huang1
1Department of Pediatrics, The First People's Hospital of Neijiang, Neijiang, Sichuan, People's Republic of China.
Journal of inflammation research
|July 30, 2025
概括
像SIRI,LMR,NAR和CAR这样的免疫炎症指标可以预测幼儿的罗塔病毒性腹风险. 一个开发出来的诺莫格拉姆模型显示了强大的预测准确度,用于识别有风险的儿童.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 罗塔病毒性腹是5岁以下儿童疾病的重要原因之一.
- 识别罗塔病毒性腹的预测标志物对于及时干预至关重要.
- 免疫炎症指标可能在轮状病毒性腹的发病和预测中发挥作用.
研究的目的:
- 调查5岁以下儿童的特定免疫炎症指标和罗塔病毒诱导的腹之间的关系.
- 使用这些指标,开发和验证罗塔病毒性腹风险的预测模型.
主要方法:
- 对439名腹儿童进行了回顾性队列研究.
- 使用LASSO,单变量和多变量逻辑回归来识别风险因素.
- 开发了一个名图模型,并使用校准图和决策曲线分析评估了它的准确性.
主要成果:
- 罗塔病毒性腹在27.33%的研究儿童中存在.
- 系统性炎症反应指数 (SIRI),淋巴细胞与单细胞比率 (LMR),中性粒细胞与白蛋白比率 (NAR) 和C反应蛋白与白蛋白比率 (CAR) 是独立的预测因素.
- 随着强大的校准,诺莫格拉姆模型在训练组中达到0.795的AUC,在验证组中达到0.787的AUC.
结论:
- 免疫炎症指标 (SIRI,LMR,NAR,CAR) 是儿童罗塔病毒性腹风险的有价值预测指标.
- 开发的诺莫格拉姆模型显示出出色的预测能力和临床实用性,用于评估轮回病毒性腹风险.
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