喘中的活性氧物种:巨细胞极化调节剂和治疗影响:叙述性综述
Ying Liu1, Mingyao Zhang2, Tongtong Wang3
1School of Chinese Medicine, Anhui University of Chinese Medicine, Hefei, Anhui Province, 230012, People's Republic of China.
Journal of asthma and allergy
|July 30, 2025
概括
反应性氧物种 (ROS) 调节喘中的巨细胞极化. 向ROS介导途径通过重新平衡M1/M2巨细胞反应和减少气道过度反应,为新的喘治疗提供了潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 巨细胞是喘中的关键免疫细胞,M1和M2亚型具有不同的作用.
- M1巨细胞促进炎症,而M2巨细胞有助于呼吸道重塑和喘中的慢性炎症.
- 反应性氧物种 (ROS) 是影响巨细胞两极分化的信号分子.
研究的目的:
- 审查喘中内源和外源ROS的来源.
- 阐明ROS影响M1/M2巨细胞两极化的机制.
- 讨论针对喘中ROS介导的巨细胞极化治疗的治疗潜力.
主要方法:
- 对ROS,巨细胞极化和喘研究的文献综述.
- 对参与ROS介导偏振的信号通路 (MAPK,NF-κB,NLRP3,STAT6) 的分析.
- 检查巨细胞标记物 (例如,ARG1,Ym1/2,Fizz1,CD206) 和它们与喘病理生理学的关联.
主要成果:
- 内生ROS源包括NOX2,丁氧化酶,过氧体和线粒体.
- 外源的ROS来源包括臭氧和细颗粒物.
- 通过不同的信号级联,ROS通过不同的信号级联不同调节M1 (促炎) 和M2 (组织修复/重塑) 巨细胞两极分化.
结论:
- 通过影响促炎M1和组织重塑M2巨表型,ROS在喘中起着双重作用.
- 通过ARG1活动,M2巨细胞有助于原沉积和气道重塑.
- 调节ROS依赖的巨细胞极化为喘治疗提供了一个有前途的治疗策略.
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