慢性病中的肠道微生物组重塑:替代疗法和治疗干预措施的含义
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Qianwei Wang1, Yucheng Han1, Liang Pang2
1Graduate School, Heilongjiang University of Chinese Medicine, Harbin, China.
Frontiers in medicine
|July 30, 2025
概括
置换疗法改变肠道细菌,影响尿液中毒素水平. 植物性饮食和便移植等干预措施显示出通过调节肠道微生物群来管理末期病 (ESRD) 的前景.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學.
- 胃肠病学 胃肠病学
背景情况:
- 末期病 (ESRD) 是一个日益严重的全球健康问题.
- 肠道微生物组通过肠-轴在脏健康方面发挥着至关重要的作用.
- 微生物失生症有助于尿素毒素的积累和ESRD中的全身炎症.
研究的目的:
- 审查血液透析 (HD) 和腹腔透析 (PD) 对肠道微生物群的不同影响.
- 在ESRD中评估针对肠道微生物组的当前治疗干预措施.
- 在ESRD中确定准确医学的未来研究方向.
主要方法:
- 关于KRT和肠道微生物组的现有文献的叙事综述.
- 对诸如益生菌,益生菌,PBD和FMT等干预措施的研究进行分析.
- 综合有关微生物变化,毒素水平和临床结果的数据.
主要成果:
- HD与特定的细菌丰富和减少有益的SCFA生产者有关.
- PD与致病性细菌的增殖和SCFA代谢受损有关.
- 像PBDs,synbiotics和FMT这样的干预措施显示出减少毒素和改善标记物的潜力.
结论:
- KRT显著影响肠道微生物的组成和功能.
- 食和微生物组向治疗为ESRD管理提供了有前途的途径.
- 用标准化方案和临床验证进行进一步的研究对于治疗进步至关重要.
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