住院固体癌症患者的维生素D和甲状腺病综合征之间的关系:一项回顾性研究
Mehmet Emin Buyukbayram1, Zekeriya Hannarici2, Aykut Turhan3
1Department of Medical Oncology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Clinical Medicine Insights. Oncology
|July 30, 2025
概括
甲状腺疾病综合征 (ESS) 在住院癌症患者中很常见,特别是那些接受支持性护理的人. ESS与表现不佳的状态,低血红蛋白和高C反应蛋白有关,但与维生素D水平无关.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 临床医学 临床医学
背景情况:
- 甲状腺疾病综合征 (ESS) 已因其与癌症分期和固体瘤的预后相关而得到认可.
- 之前的研究探讨了ESS与BMI,ECOG PS,Hb和急性相反应物等因素的联系.
- 癌症患者中ESS和25-氧维生素D [25(OH) D]之间的关系仍然不清楚.
研究的目的:
- 在住院患有固体癌症 (HSC) 的患者中调查与ESS相关的因素.
- 探讨在HSC中25...OH) D水平和ESS之间的关系.
- 确定HSC中ESS的患病率及其与临床和实验室参数的关联.
主要方法:
- 对105名患有固体癌症 (HSC) 的住院患者进行了回顾性研究.
- 从入院时的初始血液样本评估的实验室参数.
- 通过低fT3,正常/低fT4和正常TSH水平来定义ESS.
主要成果:
- 整体ESS患病率为37.1%,在支持性护理 (40.3%) 患者中高于化疗 (28.6%) 患者.
- 显著的ESS与低ECOGPS (P<.001),低Hb (P=.001) 和升高的CRP (P<.001) 相关.
- 在25...OH) D水平和ESS之间没有发现显著的关系 (P=.118).
结论:
- 在高血压患者中,ESS相对较为常见,特别是那些住院接受支持性护理的人.
- 在HSC中ESS与ECOGPS,Hb和CRP显著相关.
- 在这个患者群体中,没有发现ESS和25(OH) D之间的显著关联.
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