预测慢性疼痛管理干预结果的因素
Steven P Cohen1,2,3, Eric J Wang4, Alexandra Roybal5
1Anesthesiology, Neurology, Physical Medicine and Rehabilitation, Psychiatry, Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
BMJ medicine
|July 30, 2025
概括
慢性疼痛影响全球20%以上的人口,需要了解影响程序性疼痛缓解的因素. 本综述检查了个人,社会和临床因素影响结果超出了安慰剂效应.
科学领域:
- 疼痛医学 医学 疼痛医学
- 干预程序 干预程序
- 个性化医疗是个性化的医疗.
背景情况:
- 慢性疼痛对全球健康构成重大负担,导致严重的残疾.
- 慢性疼痛的干预治疗方法越来越多,但它们有效性的证据往往是温和的.
- 在常见疼痛干预的临床试验中,安慰剂效应经常超过治疗效应.
研究的目的:
- 对影响疼痛和程序干预的功能结果的因素进行范围审查.
- 确定影响慢性疼痛管理结果的个人,社会和临床因素.
- 探索这些因素的交叉性及其对治疗疗效的影响.
主要方法:
- 使用范围审查方法来综合现有文献.
- 该审查审查了关于慢性疼痛手术和非手术手术程序干预的研究.
- 影响疼痛和功能结果的因素被系统地确定和分析.
主要成果:
- 个人特征 (例如,遗传,心理状态) 显著影响疼痛感知和治疗反应.
- 社会因素 (例如,社会经济地位,支持系统) 在疼痛管理结果中起着至关重要的作用.
- 临床因素 (例如,并发症,治疗特征) 与个人和社会因素相互作用,影响患者的结果.
结论:
- 了解个人,社会和临床因素的相互作用对于优化程序性疼痛管理至关重要.
- 个性化医疗方法应整合这些多方面的因素,以改善患者的治疗结果.
- 需要进一步的研究来开发基于证据的策略,以解决临床实践中的这些影响因素.
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