在慢性多关节痛的情况下,用F-FDG和Ga-FAPI PET/CT进行分子成像检测结果¹⁸和⁶⁸

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Updated: Sep 13, 2025

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

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Aparna Mahalik¹, Sivasankar Kanankulam Velliangiri¹, Sanjana Ballal¹

¹Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

|July 30, 2025

概括

使用68Ga-纤维细胞激活蛋白抑制剂 (FAPI) 的新成像技术允许在慢性多关节炎患者中可视化免疫媒介组织重塑. 这提供了潜在的疾病活动和未来治疗策略的客观指标.

科学领域:

核医学是一种核医学.
免疫学免疫学免疫学
类风湿病学类风湿病学

背景情况:

使用18F-氧糖的正子发射断层扫描 (PET) 已被确立用于检测活性炎症.
在体内可视化免疫媒介组织重塑仍然是一个挑战.
激活的纤维细胞在组织重塑过程中起着关键作用.

研究的目的:

评估68Ga-纤维细胞激活蛋白抑制剂 (FAPI) 在体内可视化介质细胞和 stromal激活的潜力.
评估FAPI作为慢性多关节炎疾病活动的客观指标.
探索FAPI针对性对未来治疗干预措施的影响.

主要方法:

使用68Ga-FAPI正子发射断层扫描 (PET) 成像.
专注于一个患有慢性多关节痛的病人.
分析了FAPI在突和周围关节组织中的吸收.

主要成果:

在患者的上肢和下肢的大关节周围观察到增加的FAPI吸收.
证明了FAPI与突中的激活纤维细胞的特定结合.
在体内可视化介质细胞和 stromal 激活.

结论:

68Ga-FAPI PET成像可以在体内可视化免疫媒介组织重塑.
FAPI的摄入量作为慢性多关节炎疾病活动的潜在客观指标.
针对激活纤维细胞的FAPI的特异性表明未来的治疗应用.

关键词:

纤维细胞激活蛋白抑制剂正子发射断层扫描.纤维细胞激活蛋白抑制剂的特异性纤维细胞激活蛋白抑制剂氧化葡萄糖正子辐射断层扫描.多关节痛症多关节痛症类风湿性关节炎类风湿性关节炎

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