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传输激光光斑对比成像与光学清除相结合,使用磁共振对比剂

Polina A Timoshina^1,2,3, Yury I Surkov^1,2, Andrei E Lugovtsov⁴

¹Institute of Physics, Saratov State University, Saratov, Russia.

Lasers in surgery and medicine

|July 30, 2025

概括

磁共振对比剂增强光学清除,用于糖尿病大鼠的激光斑对比成像和光学连贯性断层扫描. 这种新的方法有助于通过分析血管变化来区分健康和糖尿病组织.

科学领域:

生物医学光学生物医学光学
医疗成像医学成像
糖尿病研究糖尿病研究

背景情况:

非侵入性光学诊断方法对于评估与糖尿病相关的血管和组织变化至关重要.
激光光斑对比成像 (LSCI) 和光学连贯性断层扫描 (OCT) 是有前途的无接触可视化技术.
开发糖尿病评估的新标准是一个重大未满足的需求.

研究的目的:

调查使用磁共振 (MR) 对比剂与LSCI和OCT的使用.
为了评估健康与糖尿病老鼠耳朵组织的差异化.
在糖尿病模型中评估MR药物诱导的动态和结构变化.

主要方法:

素诱导的1型糖尿病模型在老鼠中.
用MR对比剂 (Gadovist,Magnevist) 与LSCI和OCT一起使用.
在光学清除过程中评估散射系数 (μs) 动力学.
在老鼠耳朵血管中的血液流速的分析.

主要成果:

MR对比剂有效降低了老鼠耳部组织中的散射系数.
与Magnevist (12.6%的健康人,6.8%的糖尿病人) 相比,Gadovist在μs (18.6%的健康人,16.1%的糖尿病人) 中显示出更大的减少.
与健康对照相比,糖尿病老鼠在耳朵血管中表现出血流指标的减少.

结论:

MR对比剂是OCT和LSCI的有效光学清除剂.
这项研究开创了对糖尿病多模式光学成像中的MR剂的研究.
这些发现支持光斑成像的多式应用,以提高光学清除评估.

关键词:

在糖尿病中,糖尿病是血糖类的.激光光斑对比成像技术激光光斑对比成像技术光学清除可以通过光学清除.光学清除剂是指光学清除剂.光学连贯性断层扫描技术

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