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Updated: Sep 13, 2025

Assays for the Degradation of Misfolded Proteins in Cells
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致病性TRIM74突变破坏蛋白质平衡,并通过结构不稳定引发蛋白质毒性神经退行

S Rehan Ahmad1, Abdullah M AlShahrani2, Anupriya Kumari3

  • 1Hiralal Mazumdar Memorial College for Women, West Bengal State University, Kolkata, West Bengal 700035, India.

ACS chemical neuroscience
|July 30, 2025
PubMed
概括

一个新的TRIM74基因突变导致严重的神经发育障碍与神经退行性特征. 这种全方位酶缺陷导致蛋白质聚合和细胞死亡,影响神经元恒温.

关键词:
在TRIM74中,有74个问题.神经发育障碍是一种神经发育障碍.蛋白质聚合蛋白质的聚合物蛋白质稳定性功能障碍无处不在的合酶

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