阿瓦科班治疗ANCA相关的血管炎:超过52周的治疗周期
Clinical nephrology
|July 30, 2025
概括
延长Avacopan (AVP) 治疗超过52周,持续缓解ANCA相关血管炎 (AAV) 和改善功能. 在这项现实研究中,感染是主要的不良影响.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 类风湿病学 类风湿病学
- 临床药理学 临床药理学
背景情况:
- 在ADVOCATE试验中,在52周内确定了阿瓦科潘 (AVP) 对ANCA相关血管炎 (AAV) 的疗效.
- 在现实世界中,AVA患者的管理可能涉及超过52周的AVP治疗持续时间.
研究的目的:
- 为了评估长期阿瓦科班 (AVP) 治疗在52周的ADVOCATE试验持续时间之外,与ANCA相关的血管炎 (AAV) 的成年患者的安全性和疗效.
- 评估接受延长AVP治疗的AAV患者的长期缓解率,功能变化和不良事件.
主要方法:
- 多中心回顾性队列研究,涉及15名新发或复发的AVA的成年患者.
- 患者接受阿瓦科潘 (AVP) 治疗52周或更长时间.
- 在平均96周的随访期间,收集了关于临床结果,估计的淋巴细胞过率 (eGFR) 和不良事件的数据.
主要成果:
- 15名患者中有1人经历了AAV爆发;没有患者进展到末期脏疾病.
- 到最后一次随访时,平均eGFR比基线增加了16mL/min/1.73m2.
- 感染是最常见的不良事件 (5需要住院治疗);没有报告肝功能测试异常.
结论:
- 延长阿瓦科班 (AVP) 治疗超过52周,持续AAV缓解和eGFR改善.
- 延长AVP治疗表明,对功能和肝酶的安全性概况有利.
- 需要进一步的研究,以充分了解AVP在AAV管理中的扩大AVP使用的长期影响.
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