用格莱卡普雷维尔/皮布伦塔斯维尔治疗早期C型肝炎病毒感染的短期疗法:PURGE-C
Arthur Y Kim1, Minhee Kang2, Triin Umbleja2
1Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
概括
四周的glecaprevir/pibrentasvir (G/P) 在早期型肝炎病毒 (HCV) 感染中实现了84%的治愈率. 这种短暂的治疗过程并没有阻碍再治疗的成功,简化了关键人群的护理.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 早期型肝炎病毒 (HCV) 感染的较短治疗方案可以简化护理,特别是在关键人群中.
- 在PURGE-C试验 (A5380) 调查了为期4周的glecaprevir/pibrentasvir (G/P) 治疗早期HCV的治疗方案.
- 早期的HCV是由可检测的HCVRNA或在入学24周内ALT升高所定义的.
研究的目的:
- 为了评估早期HCV感染的4周G/P治疗疗程的疗效.
- 评估接受缩短的DAA治疗的参与者的持续病毒学反应 (SVR12) 率.
- 为了确定治疗失败对后续再治疗结果的影响.
主要方法:
- 一个单臂多中心试验 (PURGE-C,NCT04042740) 招募了45名早期HCV患者.
- 参与者接受了4周的G/P治疗.
- 主要终点是SVR12,同时也收集了重复治疗结果.
主要成果:
- 84%的参与者 (38/45) 实现了SVR12,90%的CI为74%-91%.
- 研究人口主要是男性 (98%),白人 (51%),西班牙裔 (31%),平均年龄为36岁.
- 一半的参与者同时感染了艾滋病毒 (51%),27%的人报告注射药物使用.
结论:
- 一个为期4周的G/P疗程在早期HCV感染的个体中实现了84%的治愈率.
- 这种短期疗程的治疗失败并没有对重新治疗的结果产生负面影响.
- 简化直接作用抗病毒 (DAA) 疗程为消除HCV提供了一个有希望的策略,特别是在难以接触的人群中.
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