伦瓦提尼布在不同类型的甲状腺癌中的作用
Catarina Regala1, Tiago N Silva2, Valeriano Leite2
1Department of Endocrinology, Francisco Gentil Portuguese Institute of Oncology, Lisbon, Portugal - catarinaregala@gmail.com.
Minerva endocrinology
|July 30, 2025
概括
伦瓦替尼在治疗晚期甲状腺癌,包括耐放射性类型的治疗中表现出有效性. 虽然通常是安全的,但对甲状腺癌患者的副作用需要谨慎管理.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚期和渐进的甲状腺癌 (TC),特别是放射性耐火性TC (RAIR-TC),由于预后不佳和治疗选择有限,造成了重大挑战.
- 伦瓦提尼布是一种口服的多向氨酸激酶抑制剂,已被批准用于RAIR-TC的第一线治疗.
研究的目的:
- 综合审查伦瓦提尼布在管理各种高级甲状腺癌类型中的作用.
- 评估伦瓦提尼布在抗放射性,差分化,无塑性和髓性甲状腺癌中的疗效和安全性.
主要方法:
- 在PubMed上进行了系统的文献搜索,截至2024年7月.
- 搜索术语包括"甲状腺瘤" (MeSH) 和"伦瓦提尼布" (MeSH).
- 该审查包括了伦瓦提尼布在晚期甲状腺癌管理中的研究.
主要成果:
- 伦瓦替尼在RAIR-TC中表现出显著的疗效,导致部分反应或稳定的疾病和全球监管批准.
- 在差差分化甲状腺癌 (PDTC) 中观察到潜在效用.
- 在形甲状腺癌 (ATC) 中的单一治疗显示出不一致的结果,但与免疫检查点抑制剂的联合治疗似乎很有希望. 甲状腺髓性癌 (MTC) 的数据仅限于II期研究. 副作用很常见,需要管理,有些病例导致停药或死亡.
结论:
- 伦瓦提尼布在各种甲状腺癌亚型中表现出临床疗效和可管理的安全性.
- 现实世界的数据和临床试验支持lenvatinib在治疗晚期甲状腺癌中的使用.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
5.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
5.1K
Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
The Thyroid Gland
4.4K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
4.4K
Functions of Thyroid Hormones
3.2K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
3.2K


