补充C3预测90天内细菌感染的肝硬化患者急性至慢性肝衰竭:一个队列研究
Shuling Chen1, Ruiqi Li1, Hongli Liu1
1Department of Hepatology, The Second Hospital of Nanjing, Medical School, Southeast University.
European journal of gastroenterology & hepatology
|July 30, 2025
概括
血清补充成分3 (C3) 可以预测90天的急性至慢性肝衰竭 (ACLF) 和细菌感染的肝硬化患者的死亡率. 较低的C3水平表明风险较高,有助于临床评估.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 临床诊断 临床诊断 临床诊断
背景情况:
- 细菌感染 (BI) 的肝硬化患者具有急性-慢性肝衰竭 (ACLF) 和死亡的高风险.
- 需要有效的生物标志物,以便在这个脆弱人群中进行早期风险分层.
研究的目的:
- 评估血清补充成分3 (C3) 在预测90天ACLF和BI肝硬化患者的死亡率方面的诊断价值.
- 在风险分层模型中评估C3的性能.
主要方法:
- 对105名患有BI的肝硬化患者的临床数据进行前性分析.
- 评估90天内ACLF发育和死亡率作为主要结局.
- 统计分析包括危险比率,时间依赖的ROC曲线和随机森林回归.
主要成果:
- 低血清C3水平独立预测90天内ACLF (HR:0.14) 和死亡率 (HR:0.10).
- 随着时间的推移,C3显示了ACLF (AUROC 0.72-0.76) 和死亡率 (AUROC 0.68-0.76) 的良好预测性能.
- 包括C3改善了已建立的死亡率评分系统的预测准确性.
结论:
- 血清C3是90天ACLF和细菌感染肝硬化患者死亡率的有价值的预后标志物.
- C3为风险分层提供了潜在的临床实用性,使得及时干预成为可能.
相关概念视频
Complement System
2.7K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.7K
Pleural Effusion II: Symptoms and Management
272
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
272
Diseases of the Liver and Gallbladder
1.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.0K
Acute Pyelonephritis II: Diagnostic Studies and Management
41
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
41
Acute Kidney Injury IV: Diagnostic Studies and Prevention
57
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
57
Pneumonia III: Complications and Assessment
442
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
442


