呼吸道细菌组成的变化 殖民肺炎球菌结合体 接种疫苗的儿童,2006-2023年
Frank N Salamone1, Andrew Cox1, Ravinder Kaur1
1Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY 14621, USA.
FEMS microbiology letters
|July 30, 2025
概括
13性肺炎球菌联合疫苗 (PCV13) 改变了Streptococcus pneumoniae血清型,但没有改变儿童的总体殖民率. 在健康儿童和无并发性急性中耳炎 (AOM) 中,鼻细菌与复杂的AOM不同.
科学领域:
- 儿童传染病 儿童传染病
- 疫苗学 疫苗学 疫苗学
- 微生物学 微生物学
背景情况:
- 引入13肺炎球菌合疫苗 (PCV13) 是为了减少肺炎球菌疾病的负担.
- 了解鼻殖民模式对于疫苗影响评估至关重要.
- 殖民和急性中耳炎 (AOM) 之间的关系需要持续调查.
研究的目的:
- 评估PCV13引入对儿童鼻殖民模式的影响.
- 检查鼻殖民和急性中耳炎 (AOM) 发展之间的关联.
- 分析PCV13实施后呼吸道病原体分布的变化.
主要方法:
- 在PCV7,PCV13早期和PCV13晚期期间对1537名6-36个月龄的儿童进行前性队列研究.
- 在健康访问和AOM发作期间收集的鼻腔培养.
- 在指示时进行配对 tympanocentesis;分析病原体分布和血清型变化.
主要成果:
- PCV13的引入导致了Streptococcus pneumoniae中的血清型替代,但整体殖民率稳定.
- 海莫菲勒斯流感的发病率保持不变,而莫拉塞拉白内障的发病率增加.
- 鼻病原体分布在健康/无并发性AOM和复杂的AOM病例之间有显著差异.
- 鼻培养是中耳液分离的糟糕预测指标.
结论:
- PCV13有效地取代了目标血清型,但没有减少整体肺炎球菌鼻运输.
- 对于不复杂的与复杂的AOM存在不同的呼吸道病原体概况.
- 在PCV13后鼻殖民模式的变化对AOM流行病学有影响.
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