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血清阴性慢性甲状腺炎:一种阴险的鼻图实体,导致甲状腺功能低下,和难以切除甲状腺的原因
Giuseppe Santangelo1,2, Elvira La Mantia3, Immacolata Cozzolino3
1Section of General Surgery, Department of General and Specialistic Surgery, A.S.L.Salerno, Hospital of Eboli, Salerno, Italy. pippo_santangelo@libero.it.
Endocrine
|July 30, 2025
概括
抗体阴性慢性甲状腺炎是一种独特的疾病,类似于抗体阳性甲状腺炎. 它与术后缺甲状腺症和术前甲状腺功能低下症的风险增加有关.
科学领域:
- 内分泌学 在内分泌学.
- 甲状腺学 甲状腺学
- 手术病理学手术病理学
背景情况:
- 慢性卵泡甲状腺炎通常与自身抗体有关.
- 抗体阴性慢性卵泡甲状腺炎的存在已被假设,但缺乏明确的组织学诊断.
- 了解这种实体对于准确的诊断和患者管理至关重要.
研究的目的:
- 在怀疑抗体阴性慢性卵泡甲状腺炎的患者中,将组织病理学发现与临床和手术结果相关联.
- 与抗体阳性和无甲状腺炎组相比,研究血清阴性甲状腺炎的临床意义.
- 确定不同类型的甲状腺炎与手术并发症或手术前甲状腺功能低下症之间的关联.
主要方法:
- 在2014年11月至2020年10月期间,对476名接受甲状腺切除术的患者进行了回顾性分析.
- 根据抗体水平和组织学,分类为三组:没有甲状腺炎 (TF),抗体阳性甲状腺炎 (SPT) 和血清阴性甲状腺炎 (SNT).
- 在各组中对手术并发症 (甲状腺功能低下,神经麻,出血) 和手术前甲状腺功能低下的统计比较.
主要成果:
- 与TF (6.5%) 相比,SPT (14.7%) 和SNT (13.2%) 组中过渡性偏偏甲状腺症的发病率显著更高.
- 与TF (6.2%) 相比,SPT (33.6%) 和SNT (23.7%) 组的甲状腺功能低下的患病率显著更高,SPT和SNT之间的患病率相似.
- 在两组之间,在永久性副甲状腺功能低下,复发性喉神经麻或术后出血方面没有发现显著差异.
结论:
- 慢性阴性血清性甲状腺炎是一种独特的鼻图学实体,与抗体阳性慢性甲状腺炎相当.
- 血清阴性甲状腺炎在统计学上与术后偏偏甲状腺症和术前低甲状腺症的增加相关.
- 这种情况有助于甲状腺功能低下,喉 (即使没有缺),以及潜在的困难甲状腺切除术.
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