坚果消费,肠道微生物群和认知功能:一项针对老年人进行的前性研究发现,他们面临认知能力下降的风险
Jiaqi Ni1,2,3, Stephanie K Nishi1,2,3,4,5, Nancy Babio1,2,3
1Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Alimentació, Nutrició, Desenvolupament i Salut Mental ANUT-DSM, Reus, Tarragona, Spain.
Age and ageing
|July 30, 2025
概括
适度的坚果消费 (每周3-7份) 与老年人保持认知功能和更健康的肠道微生物组有关. 这突出了肠-大脑轴.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 微生物组研究 微生物组研究
背景情况:
- 饮食-微生物群-肠道-大脑轴是预防神经退行性疾病的关键领域.
- 坚果提供神经保护和益生菌的好处,但它们对认知和肠道微生物群的影响尚未完全理解.
研究的目的:
- 为了研究基线坚果消费与六年内认知变化之间的关联.
- 检查老年人中坚果摄入量和肠道微生物群组成之间的关系.
主要方法:
- 对747名参与者 (平均年龄65岁) 进行前性研究,这些参与者患有超重/肥胖和代谢综合征.
- 坚果消费量通过食物频率问卷 (份/周) 进行评估.
- 使用神经心理测试评估认知功能;使用16S rRNA测序对肠道微生物群进行分析.
主要成果:
- 摄入3-7份坚果/周与较慢的全球认知衰退相关,而≤1份/周.
- 这种摄入水平也与更高的肠道微生物多样性 (香农指数) 有关.
- 特定的肠道细菌,如Lachnospiraceae UCG-004,与坚果消费和认知能力的改善有关.
结论:
- 适度的坚果消费 (每周3-7份) 与认知保存相互关联.
- 良好的肠道微生物组成与适度的坚果摄入有关.
- 肠-大脑轴的饮食调节显示出健康衰老的潜力.
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