添加西姆瓦斯塔丁到标准护理改善了患有肝硬化病的患者的长期生存经过腹出血后:一个开放标签随机对照试验
Randeep Rana1, Mohammed Tabish, Samagra Agarwal
1Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, India.
The American journal of gastroenterology
|July 30, 2025
概括
补充simvastatin标准护理显著改善了经过水出血后肝硬化患者的存活率. 它还减少了炎和自发细菌性腹膜炎的发生率.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 临床药理学 临床药理学
背景情况:
- 关于simvastatin在去补偿性肝硬化中有效性和安全性的证据有限.
- 腹出血是肝硬化患者的严重并发症,需要有效的管理策略.
研究的目的:
- 评估simvastatin是否可以改善肝硬化患者的长期存活率.
- 评估simvastatin作为标准护理的辅助剂的安全性和有效性.
主要方法:
- 进行了一项单中心,开放标签,随机对照试验.
- 肝硬化患者 (查尔德 - 普格评分5-12) 在标准治疗中接受了simvastatin (20 mg/天) 或没有药物.
- 主要结局是24个月的全因死亡率.
主要成果:
- 西姆瓦斯塔丁的使用与所有原因死亡率显著降低有关 (HR 0.48;P=0.006).
- 炎和自发性细菌性腹膜炎的发生率在西姆瓦斯塔丁组较低.
- 两组之间没有观察到严重不良事件的显著差异.
结论:
- 辛瓦斯可以改善精选的肝硬化患者在水出血后的存活率.
- 辅助的simvastatin治疗可以减少风及其并发症的发生率.
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