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Updated: Sep 13, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

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热力学不稳定性和结构适应性2'-Alkoxy/Fluoro-N3-甲基胺核酸在siRNA增强RNA干扰活动

Avijit Sahoo1, Shalini Gupta2, Gourav Das1

  • 1Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal 721302, India.

Journal of medicinal chemistry
|July 30, 2025
PubMed
概括

小型干扰RNAs (siRNAs) 中的新型2'-alkoxy/fluoro-m3C修饰增强了RNA干扰 (RNAi) 的活性和稳定性. 这些修改后的siRNAs显示出改善的核酶抗性,并保持无免疫刺激作用的沉默效果.

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