相关实验视频

Updated: Sep 13, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

68.9K

PLMFit:比较转移学习与蛋白质语言模型用于蛋白质工程.

Thomas Bikias1,2, Evangelos Stamkopoulos1,2, Sai T Reddy1,2

  • 1Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

Briefings in bioinformatics
|July 30, 2025
PubMed
概括

蛋白质语言模型 (PLM) 与转移学习 (TL) 结合,提供了强大的蛋白质工程工具. 我们的研究对不同的TL方法进行了基准测试,发现微调 (FT) 对于有限的数据和概括需求是最好的.

关键词:
基准测试 (benchmarking) 是一种比较的方法.参数高效的微调.蛋白质工程工程 蛋白质工程蛋白质健身 蛋白质健身是一种健身.蛋白质语言模型的模型转移学习转移学习

更多相关视频

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

2.0K
A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports07:35

A Knowledge Graph Approach to Elucidate the Role of Organellar Pathways in Disease via Biomedical Reports

Published on: October 13, 2023

1.7K

相关概念视频

Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
11.4K
Protein Networks02:26

Protein Networks

2.4K
Improving Translational Accuracy02:07

Improving Translational Accuracy

2.7K
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
13.3K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
12.8K
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

3.8K